Protein crosslinks: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs) |
Eric Martz (talk | contribs) |
||
| Line 3: | Line 3: | ||
==Natural Crosslinks== | ==Natural Crosslinks== | ||
*<big>[[Disulfide bonds]]</big> are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds | *<big>[[Disulfide bonds]]</big> are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds | ||
(July, 2021<ref>In July, 2021, the PDB had ~180,000 entries. Advanced search for "Polymer molecuar features: polymer entity type = protein" and "Deposited entry features: Disulfide bond count per deposited model > 0" gave ~41,000 hits, or about 23%.</ref>). | (July, 2021<ref>In July, 2021, the PDB had ~180,000 entries. Advanced search at RCSB.Org for "Polymer molecuar features: polymer entity type = protein" and "Deposited entry features: Disulfide bond count per deposited model > 0" gave ~41,000 hits, or about 23%.</ref>). | ||
Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | ||
**Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | **Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | ||
