2w50: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W50 FirstGlance].

<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2W50 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [~~http~~://pdbe.org/2w50 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [https://pdbe.org/2w50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [https://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

[[https://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 <StructureSection load='2w50' size='340' side='right'caption='[[2w50]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [http://pdbe.org/2w50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [http://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [https://pdbe.org/2w50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [https://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
+[[https://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]