Dynactin

spinqualitylabelsall models Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion 2hl5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Dynactin (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules. See also CAP-Gly domain. Disease Mutant dynactin was found in motor neuron disease. Structural highlights Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1 (2hl5).

3D Structures of Dynactin

Updated on 11-July-2021

CAP-Gly domain, 2hl5 - hDCTN subunit 1 CAP-Gly domain – human – NMR
2hkn - hDCTN subunit 1 CAP-Gly domain
3e2u – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1
2hkq, 2hl3, 1txq - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal
2hqh - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain
2hl5, 3tq7 - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal
3tv0 - hDCTN subunit 6
5adx – pDCTN subunits 2,3,5,6 + actin-related protein + actin + capping protein – pig – CryoEM
6f1t, 6f38, 6f3a, 6f1u – pDCTN subunits 1,2,3,4,5,6 + dynein tail + capping protein + actin-related protein – CryoEM
6znl, 6zno – pDCTN subunits 1,2,4,5,6 + actin + actin-related protein + ADP + ATP – CryoEM
6znm – pDCTN subunits 2,5,6 + actin + actin-related protein + BICDR1 + ADP + ATP – CryoEM
6znn – pDCTN subunits 2,4,5,6 + actin + actin-related protein + BICD2 + ADP + ATP – CryoEM
5afu, 5nw4 – pDCTN subunits 2,3,5,6 + dynein tail + capping protein – CryoEM
4rfx - DCTN subunit 1 coiled coil 1 domain (mutant) - chicken
2m02 - DCTN subunit 1 CAP-Gly domain – rat – NMR

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Michal Harel, Alexander Berchansky