7c36: Difference between revisions
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==c-Myc DNA binding protein structure== | ==c-Myc DNA binding protein structure== | ||
<StructureSection load='7c36' size='340' side='right'caption='[[7c36]]' scene=''> | <StructureSection load='7c36' size='340' side='right'caption='[[7c36]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[7c36]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C36 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c36 OCA], [https://pdbe.org/7c36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c36 RCSB], [https://www.ebi.ac.uk/pdbsum/7c36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c36 ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBMS1, C2orf12, MSSP, MSSP1, SCR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c36 OCA], [https://pdbe.org/7c36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c36 RCSB], [https://www.ebi.ac.uk/pdbsum/7c36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c36 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/RBMS1_HUMAN RBMS1_HUMAN]] Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
DNA binding proteins recognize DNA specifically or non-specifically using direct and indirect readout mechanisms like sliding, hopping, and diffusion. However, a common difficulty in explicitly elucidating any particular mechanism of site-specific DNA-protein recognition is the lack of knowledge regarding target sequences and inadequate account of non-specific interactions, in general. Here, we decipher the structural basis of target search performed by the key regulator of expression of c-myc proto-oncogene, the human RBMS1 protein. In this study, we have shown the structural reorganization of this multi-domain protein required for recognizing the specific c-myc promoter sequence. The results suggest that a synergy between structural re-organization and thermodynamics is necessary for the recognition of target sequences. The study presents another perspective of looking at the DNA-protein interactions. | |||
Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter.,Aggarwal P, Bhavesh NS Nucleic Acids Res. 2021 Jun 4;49(10):5943-5955. doi: 10.1093/nar/gkab363. PMID:33999211<ref>PMID:33999211</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7c36" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aggarwal P]] | [[Category: Aggarwal, P]] | ||
[[Category: Bhavesh | [[Category: Bhavesh, N S]] | ||
[[Category: C-myc binding]] | |||
[[Category: Dna binding]] | |||
[[Category: Dna binding protein]] | |||
Revision as of 10:04, 14 July 2021
c-Myc DNA binding protein structure
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