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'''X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.''' | '''X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.''' | ||
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[[Category: Lima, C D.]] | [[Category: Lima, C D.]] | ||
[[Category: Mossessova, E.]] | [[Category: Mossessova, E.]] | ||
[[Category: | [[Category: Covalent protease adduct]] | ||
[[Category: | [[Category: Cysteine protease]] | ||
[[Category: | [[Category: Nabh4]] | ||
[[Category: | [[Category: Smt3 hydrolase desumoylating enzyme]] | ||
[[Category: | [[Category: Smt3 processing enzyme]] | ||
[[Category: | [[Category: Sumo hydrolase]] | ||
[[Category: | [[Category: Sumo processing enzyme]] | ||
[[Category: | [[Category: Thiohemiacetal]] | ||
[[Category: | [[Category: Ubiquitin-like protease 1]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:32:36 2008'' | |||
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Revision as of 12:32, 2 May 2008
X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.
Overview
Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear processes and cell cycle progression in yeast. The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular substrate Smt3, the yeast SUMO homolog. The Ulp1-Smt3 crystal structure and functional testing of elements within the conserved interface elucidate determinants of SUMO recognition, processing, and deconjugation. Genetic analysis guided by the structure further reveals a regulatory element N-terminal to the proteolytic domain that is required for cell growth in yeast.
About this Structure
1EUV is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast., Mossessova E, Lima CD, Mol Cell. 2000 May;5(5):865-76. PMID:10882122 Page seeded by OCA on Fri May 2 15:32:36 2008
