1dnn

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

SMOOTH BENDING OF DNA IN CHROMATIN

spinqualitylabelsall models 1dnn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, PDBsum, ProSAT Publication Abstract from PubMed The idea that DNA in chromatin can be packed smoothly, without breaking of base-stacking interactions, has been explored by both energetical estimations and stereochemical model building. A model of deformed DNA is built that fits reasonably to the known dimensions of a nucleosome. The model has slightly changed torsion angles in the sugarphosphate moieties relative to B DNA, varying gradually along the chains. The angle between planes of adjacent base pairs varies between 1 and 7 degrees. This model of deformed DNA does not have any unusually close nonbonded contacts and is evidently not the only possible model of smooth packing of DNA in chromatin. An energetical estimation of the critical radius of curvature of a smoothly bent DNA molecule is made using approximate potential functions for different van der Waals contracts in the B DNA structure. The critical radius of curvature of the deformed DNA-axis is close to the radius of a nucleosome (similar to 50 A). The smooth packing is a good alternative to models of kinked folding of DNA in nucleosomes. Possibility of nonkinked packing of DNA in chromatin.,Sussman JL, Trifonov EN Proc Natl Acad Sci U S A. 1978 Jan;75(1):103-7. PMID:272625 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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