6n44: Difference between revisions
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==Sheep Galectin-11 (LGALS11) complex with glycerol== | ==Sheep Galectin-11 (LGALS11) complex with glycerol== | ||
<StructureSection load='6n44' size='340' side='right'caption='[[6n44]]' scene=''> | <StructureSection load='6n44' size='340' side='right'caption='[[6n44]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N44 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6n44]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_ammon_aries Ovis ammon aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N44 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n44 OCA], [https://pdbe.org/6n44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n44 RCSB], [https://www.ebi.ac.uk/pdbsum/6n44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n44 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Galectins are a family of glycan-binding molecules with a characteristic affinity for ss-D-glycosides that mediate a variety of important cellular functions, including immune and inflammatory responses. Galectin-11 (LGALS-11) has been recently identified as a mediator induced specifically in animals against gastrointestinal nematodes and can interfere with parasite growth and development. Here, we report that at least two natural genetic variants of LGALS-11 exist in sheep, and demonstrate fundamental differences in anti-parasitic activity, correlated with their ability to dimerise. This study improves our understanding of the role of galectins in the host immune and inflammatory responses against parasitic nematodes and provides a basis for genetic studies toward selective breeding of animals for resistance to parasites. | |||
The oligomeric assembly of galectin-11 is critical for anti-parasitic activity in sheep (Ovis aries).,Sakthivel D, Preston S, Gasser RB, Costa TPSD, Hernandez JN, Shahine A, Shakif-Azam MD, Lock P, Rossjohn J, Perugini MA, Gonzalez JF, Meeusen E, Piedrafita D, Beddoe T Commun Biol. 2020 Aug 21;3(1):464. doi: 10.1038/s42003-020-01179-7. PMID:32826940<ref>PMID:32826940</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6n44" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Galectin 3D structures|Galectin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Beddoe | [[Category: Ovis ammon aries]] | ||
[[Category: Sakthivel D]] | [[Category: Beddoe, T C]] | ||
[[Category: Sakthivel, D]] | |||
[[Category: Galectin]] | |||
[[Category: Glycan binding]] | |||
[[Category: Lectin]] | |||
[[Category: Sugar binding protein]] | |||
