Glycoprotein GP: Difference between revisions

Latest revision as of 10:01, 11 August 2021

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Ebolavirus glycosylated GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code 3s88)

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 == Function ==
-The virus contains a surface '''glycoprotein PG''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes.  GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>.  Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor.  The GP2 subunit is thought to mediate membrane fusion.
+The virus contains a surface '''glycoprotein GP''' or '''envelope glycoprotein GP''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes.  GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>.  Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor.  The GP2 subunit is thought to mediate membrane fusion.
 For details see [[GP1 of Lassa Virus]].