Signal transduction: Difference between revisions
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Receptors that activate this pathway (Phospholipase C) are mainly [[G protein-coupled receptors]] coupled to the Gαq subunit, including: | Receptors that activate this pathway (Phospholipase C) are mainly [[G protein-coupled receptors]] coupled to the Gαq subunit, including: | ||
*5-HT2 serotonergic receptors ([[5-hydroxytryptamine receptor#Structural highlights/Specific Function of 5-HT2B]]). | *5-HT2 serotonergic receptors ([[5-hydroxytryptamine receptor#Structural highlights/Specific Function of 5-HT2B]]). | ||
*α1 adrenergic receptors | |||
α1 | *Calcitonin receptors | ||
*[[Histamine H1 receptor]]. The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C (see Unique bidirectional interactions of Phospholipase C beta 3 with G alpha Q and the inositol triphosphate (IP3) signalling pathway. When a ligand binds to a G protein-coupled receptorthat is coupled to a Gq heterotrimeric G protein, the α-subunit of Gq can bind to and induce activity in the PLC isozyme PLC-β, which results in the cleavage of PIP2 into IP3 and DAG. | |||
Calcitonin receptors | |||
H1 histamine receptors | |||
Metabotropic glutamate receptors, Group I | Metabotropic glutamate receptors, Group I | ||
