1s8k: Difference between revisions
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<StructureSection load='1s8k' size='340' side='right'caption='[[1s8k]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | <StructureSection load='1s8k' size='340' side='right'caption='[[1s8k]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1s8k]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1s8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S8K FirstGlance]. <br> | ||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1du9|1du9]], [[1pnh|1pnh]], [[1acw|1acw]], [[1scy|1scy]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1du9|1du9]], [[1pnh|1pnh]], [[1acw|1acw]], [[1scy|1scy]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s8k OCA], [https://pdbe.org/1s8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s8k RCSB], [https://www.ebi.ac.uk/pdbsum/1s8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s8k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/KA171_MESMA KA171_MESMA]] Blocker of potassium channels, which inhibits both the delayed rectifier and fast transient potassium current. The inhibition is reversible and voltage-independent. It causes a depolarizing shift of the steady-state activation curve of the currents, without changing their steady-state inactivation behavior.<ref>PMID:12906891</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
