Disease
Influenza A causes the infectious respiratory disease Influenza, more commonly known as the Flu.[1] Influenza has several symptoms associated with it: fever, sore throat, runny nose, headache, muscle pain, and fatigue to severe and in some cases lethal pneumonia resultant from either influenza virus or bacterial infection in the lower respiratory tract.[2] The CDC estimated in 2019-2020 that the overall burden of Influenza was 35 million Flu-related illnesses, 16 million Flu-related medical visits, 380,000 Flu-related hospitalizations, and 20,000 Flu-related deaths [1]. The WHO estimated the global impact of annual Flu epidemics resulted in 3 to 5 million cases of severe illness, and about 290,000 to 650,000 respiratory deaths [2]. Multiple types of vaccines against Influenza currently exist: inactivated influenza vaccines (IIV4s), recombinant influenza vaccine (RIV4), and live attenuated influenza vaccine (LAIV4).[3]
Viral RNA Classification
Function of RNA Dependent RNA Polymerases
Structural Features
Viral RNA Transcription and Translation
Conservation within Influenza A RDRP
Possible Scenes
1) Scene that shows the nucleotide entry site
2) Scene showing conserved motifs/ residues
3) Scene showing the catalytic site (space-filling to show how things fit)
4) Scene that colors the different subunits, such as PB1
5) Scene that shows the areas that undergo conformation changes, maybe even a scene that shows what the conformation changes are like
- ↑ Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, Garcia-Sastre A. Influenza. Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. PMID:29955068 doi:https://dx.doi.org/10.1038/s41572-018-0002-y
- ↑ Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, Garcia-Sastre A. Influenza. Nat Rev Dis Primers. 2018 Jun 28;4(1):3. doi: 10.1038/s41572-018-0002-y. PMID:29955068 doi:https://dx.doi.org/10.1038/s41572-018-0002-y
- ↑ Grohskopf LA, Alyanak E, Ferdinands JM, Broder KR, Blanton LH, Talbot HK, Fry AM. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021-22 Influenza Season. MMWR Recomm Rep. 2021 Aug 27;70(5):1-28. doi: 10.15585/mmwr.rr7005a1. PMID:34448800 doi:https://dx.doi.org/10.15585/mmwr.rr7005a1
