Sandbox Reserved 1687: Difference between revisions
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==RNA Classification== | ==RNA Classification== | ||
Ebola is part of the Filoviridae family of single-stranded negative-sense RNA viruses of approximately 19 kb.<ref>PMID:31567063</ref> The 19 kb RNA encodes for “glycoproteins (i.e., GP, sGP, ssGP), nucleoproteins, virion proteins (i.e., VP 24, 30, 40) and the RNA dependent RNA polymerase”.<ref>PMID:31806422</ref> In EBOV, the RNA dependent RNA polymerase in conjunction with NP, VP30, and VP35 form the RNP complex in viral genome transcription and replication.<ref>PMID:31806422</ref> RDRP binds to the 3’ leader promoter and changes EBOV’s negative-sense RNA into positive-sense messenger RNA to produce Ebola proteins that produce new viral particles (virions).<ref>PMID:31806422</ref> | Ebola is part of the Filoviridae family of single-stranded negative-sense RNA viruses of approximately 19 kb.<ref>PMID:31567063</ref> The 19 kb RNA encodes for “glycoproteins (i.e., GP, sGP, ssGP), nucleoproteins, virion proteins (i.e., VP 24, 30, 40) and the RNA-dependent RNA polymerase”.<ref>PMID:31806422</ref> In EBOV, the RNA dependent RNA polymerase in conjunction with NP, VP30, and VP35 form the RNP complex in viral genome transcription and replication.<ref>PMID:31806422</ref> RDRP binds to the 3’ leader promoter and changes EBOV’s negative-sense RNA into positive-sense messenger RNA to produce Ebola proteins that produce new viral particles (virions).<ref>PMID:31806422</ref> | ||
==Function of RNA-Dependent RNA Polymerase== | ==Function of RNA-Dependent RNA Polymerase== | ||
RNA dependent RNA polymerases (RdRp) are critical to the replication of RNA viruses.<ref>DOI:10.1038/s41598-018-22328-3</ref> | RNA-dependent RNA polymerases (RdRp) are critical to the replication of RNA viruses.<ref>DOI:10.1038/s41598-018-22328-3</ref> | ||
==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase== | ==Structural Features of Ebola Virus RNA-Dependent RNA Polymerase== | ||
