3ida: Difference between revisions

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==Thermostable Cocaine Esterase with mutations L169K and G173Q, bound to DTT adduct==
==Thermostable Cocaine Esterase with mutations L169K and G173Q, bound to DTT adduct==
<StructureSection load='3ida' size='340' side='right' caption='[[3ida]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3ida' size='340' side='right'caption='[[3ida]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ida]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_sp._atcc_49955 Corynebacterium sp. atcc 49955]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ida]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_sp._atcc_49955 Corynebacterium sp. atcc 49955]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IDA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DBC:(4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL'>DBC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DBC:(4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL'>DBC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i2k|3i2k]], [[3i2j|3i2j]], [[3i2i|3i2i]], [[3i2g|3i2g]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i2k|3i2k]], [[3i2j|3i2j]], [[3i2i|3i2i]], [[3i2g|3i2g]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cocE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=51612 Corynebacterium sp. ATCC 49955])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cocE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=51612 Corynebacterium sp. ATCC 49955])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ida FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ida OCA], [http://pdbe.org/3ida PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ida RCSB], [http://www.ebi.ac.uk/pdbsum/3ida PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ida ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ida FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ida OCA], [https://pdbe.org/3ida PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ida RCSB], [https://www.ebi.ac.uk/pdbsum/3ida PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ida ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM]] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>   
[[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM]] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Corynebacterium sp. atcc 49955]]
[[Category: Corynebacterium sp. atcc 49955]]
[[Category: Large Structures]]
[[Category: Nance, M R]]
[[Category: Nance, M R]]
[[Category: Tesmer, J J.G]]
[[Category: Tesmer, J J.G]]
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