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==Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726==
==Structure of Human Cytochrome P450 1A1 with Duocarmycin Prodrug (S) ICT-2726==
<StructureSection load='6udm' size='340' side='right'caption='[[6udm]]' scene=''>
<StructureSection load='6udm' size='340' side='right'caption='[[6udm]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UDM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UDM FirstGlance]. <br>
<table><tr><td colspan='2'>[[6udm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UDM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6udm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6udm OCA], [http://pdbe.org/6udm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6udm RCSB], [http://www.ebi.ac.uk/pdbsum/6udm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6udm ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=Q4P:[(8S)-8-(chloromethyl)-7,8-dihydro-6H-furo[3,2-e]indol-6-yl](5-fluoro-1H-indol-2-yl)methanone'>Q4P</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP1A1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6udm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6udm OCA], [https://pdbe.org/6udm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6udm RCSB], [https://www.ebi.ac.uk/pdbsum/6udm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6udm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/CP1A1_HUMAN CP1A1_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bart AG]]
[[Category: Bart, A G]]
[[Category: Scott EE]]
[[Category: Scott, E E]]
[[Category: Cyp1a1]]
[[Category: Duocarmycin]]
[[Category: Oxidoreductase]]
[[Category: P450]]
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