2ktx: Difference between revisions

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<StructureSection load='2ktx' size='340' side='right'caption='[[2ktx]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
<StructureSection load='2ktx' size='340' side='right'caption='[[2ktx]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ktx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Andma Andma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KTX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ktx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Andma Andma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTX FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktx OCA], [http://pdbe.org/2ktx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ktx RCSB], [http://www.ebi.ac.uk/pdbsum/2ktx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktx ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktx OCA], [https://pdbe.org/2ktx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktx RCSB], [https://www.ebi.ac.uk/pdbsum/2ktx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA]] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.  
[[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA]] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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