Sandbox Reserved 1684: Difference between revisions
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Felix Valero (talk | contribs) No edit summary |
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== Conserved sites/residues == | == Conserved sites/residues == | ||
Once the template strand is bound and NTP entry tunnel is formed, we can find several conserved basic residues (<scene name='89/891374/Binding_to_gtp/ | Once the template strand is bound and NTP entry tunnel is formed, we can find several conserved basic residues (<scene name='89/891374/Binding_to_gtp/3'>Arg 163, Lys 167, Arg 17</scene>4) that were previously described binding the RdRd to the template strand. | ||
There is a kink at the top of the NTP entry tunnel which is stabilized by hydrogen bonding interactions involving Pro40, Glu47, and Arg49. these residues are higly conserved across picornaviruses , suggesting that the kink is common to all these viral polymerases. | There is a kink at the top of the NTP entry tunnel which is stabilized by hydrogen bonding interactions involving Pro40, Glu47, and Arg49. these residues are higly conserved across picornaviruses , suggesting that the kink is common to all these viral polymerases. | ||
