Sandbox Reserved 1683: Difference between revisions
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==Influenza A Basic Structure== | ==Influenza A Basic Structure== | ||
Influenza A itself is made of three subunits: <scene name='89/891373/Pa_subunit_breakdown/ | Influenza A itself is made of three subunits: <scene name='89/891373/Pa_subunit_breakdown/2'>PA</scene>, <scene name='89/891373/Pb1_subdomain/3'>PB1</scene>, and <scene name='89/891373/Pb2_subunit_breakdown/1'>PB2</scene>. The PA subunit contains the endonuclease which is responsible for cleaving the transcript that had been pirated from the host 10-12 nucleotides downstream of its 5' cap.<ref name="Pflug">PMID:28115197</ref> The PB1 subunit showcases the characteristic fingers, palm, and thumb domain of other RDRPs in addition to the central active site where the RNA synthesis occurs.<ref name="Pflug" /> The PB2 subunit is likely involved in separating the two strands of the template product within the active site and directs them into their respective exit tunnels.<ref name="Pflug" /> | ||
== Structural Features<ref name="Venkataraman" /> == | == Structural Features<ref name="Venkataraman" /> == | ||