Sandbox Reserved 1688: Difference between revisions

Revision as of 07:03, 25 October 2021 view source Kody Witham (talk \| contribs) 42 edits No edit summary ← Older edit		Revision as of 05:32, 26 October 2021 view source Kody Witham (talk \| contribs) 42 edits No edit summary Newer edit →
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	The fingers domain help with guiding the RNA into the active site. More specifically, the RNA interacts directly with residues 14, 93, 95, 97, 98, 139, 141, and 160. A <scene name='89/891378/Residues_with_rna/2'>Space Fill</scene> diagram better shows these interactions.		The fingers domain help with guiding the RNA into the active site. More specifically, the RNA interacts directly with residues 14, 93, 95, 97, 98, 139, 141, and 160. A <scene name='89/891378/Residues_with_rna/2'>Space Fill</scene> diagram better shows these interactions. The active site is "encircled" due to interactions between the thumb and fingers domain. In many polymerases, this structure undergoes a tightening conformation change when the substrate is bound. The HCV RdRp undergoes very minimal conformation change between bound and unbound active sites. The RdRp performs efficiently in native conformation.

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