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==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1==
==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1==
<StructureSection load='1npu' size='340' side='right'caption='[[1npu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1npu' size='340' side='right'caption='[[1npu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1npu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NPU FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b88|1b88]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npu OCA], [https://pdbe.org/1npu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npu RCSB], [https://www.ebi.ac.uk/pdbsum/1npu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npu ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1npu TOPSAN]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDCD1 OR PD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1npu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npu OCA], [http://pdbe.org/1npu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1npu RCSB], [http://www.ebi.ac.uk/pdbsum/1npu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1npu ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1npu TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PDCD1_MOUSE PDCD1_MOUSE]] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 20: Line 16:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npu ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npu ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that PD-1 is monomeric both in solution as well as on cell surface, in contrast to CTLA-4 and other family members that are all disulfide-linked homodimers. Furthermore, our structure-based mutagenesis studies identify the ligand binding surface of PD-1, which displays significant differences compared to those present in the other members of the family.
Structural and functional analysis of the costimulatory receptor programmed death-1.,Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC Immunity. 2004 Mar;20(3):337-47. PMID:15030777<ref>PMID:15030777</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1npu" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Almo SC]]
[[Category: Almo, S C]]
[[Category: Burley SK]]
[[Category: Burley, S K]]
[[Category: Cao E]]
[[Category: Cao, E]]
[[Category: Chen L]]
[[Category: Chen, L]]
[[Category: Guo X]]
[[Category: Guo, X]]
[[Category: Nathenson SG]]
[[Category: Structural genomic]]
[[Category: Schwartz J-CD]]
[[Category: Nathenson, S G]]
[[Category: Zhang X]]
[[Category: Schwartz, J C.D]]
[[Category: Zhang Z-Y]]
[[Category: Zhang, X]]
[[Category: Zhang, Z Y]]
[[Category: Ig v-type domain]]
[[Category: Immune system]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]

Revision as of 15:03, 27 October 2021

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1

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