1wt9: Difference between revisions
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<StructureSection load='1wt9' size='340' side='right'caption='[[1wt9]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='1wt9' size='340' side='right'caption='[[1wt9]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wt9]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1wt9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WT9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iod|1iod]], [[1y17|1y17]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iod|1iod]], [[1y17|1y17]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wt9 OCA], [https://pdbe.org/1wt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wt9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wt9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/SLAA_DEIAC SLAA_DEIAC]] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX and factor X in the presence of calcium with a 1 to 1 stoichiometry. Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of vWF. Is devoid of hemorrhagic and lethal activities. Possess antithrombotic and thrombolytic activities. Also hydrolyzes the Aalpha-chain of fibrinogen. Does not affect the Bbeta-chain and the gamma chain (By similarity). [[https://www.uniprot.org/uniprot/SLAB_DEIAC SLAB_DEIAC]] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX and factor X in the presence of calcium with a 1 to 1 stoichiometry. Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of vWF. Is devoid of hemorrhagic and lethal activities. Possess antithrombotic and thrombolytic activities. Also hydrolyzes the Aalpha-chain of fibrinogen. Does not affect the Bbeta-chain and the gamma chain (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 16:26, 27 October 2021
crystal structure of Aa-X-bp-I, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus
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