Androgens: Difference between revisions

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<StructureSection load='' size='340' side='right' caption='Human androgen receptor ligand-binding domain complex with modulator (PDB code [[3b5r]])' scene='54/543362/Cv/1'>
<StructureSection load='' size='340' side='right' caption='Human androgen receptor ligand-binding domain complex with modulator (PDB code [[3b5r]])' scene='54/543362/Cv/1'>
This is a default text for your page '''Androgens'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
*[[Androgen receptor]]
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
*[[Heat shock factor]] (HSF) are transcriptional activators of heat shock genes.  HSF bind to heat shock sequence elements throughout the genome with a consensus array of three oppositely oriented sequence AGGAN and activate transcription. Each HSF monomer contains one C-terminal and 3 N-terminal leucine zippers. Two sequences flanking the N-terminal leucine zippers contain the consensus nuclear localization signal (NLS). The DNA-binding domain (DBD residues 193-281)  of HSF lies in the N-terminal of the first NLS region<ref>PMID:8441385</ref>. Depletion of HSF-1 is associated with accumulation of pathogenic [[androgen receptor]] in neurodegenerative diseases<ref>PMID:23360996</ref>.
 
*[[Cellular retinoic acid-binding protein]] (CRABP); Epididymal RABP (ERABP) is an '''androgen'''-dependent RABP present in the lumen of the epididymis believed to be involved in '''sperm''' maturation. ERABP binds specifically all-trans- and 9-cis-RA.
== Function ==
*[[Aromatase]]. The primary function of aromatase is to produce estrogens by aromatizing '''androgens'''. Aromatase is the only known enzyme in vertebrates capable of catalyzing the aromatization of a six-membered ring<ref name="structure"> Ghosh, D., Griswold, J., Erman, M., Pangborn, W. " X-ray Structure of Human Aromatase Reveals An Androgen-Specific Active Site" ''Journal of Steroid Biochemistry and Molecular Biology''. [Online] '''2010''',Vol. 118, Issue 4-5, p197-202[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826573/]</ref>.
 
*[[Student Project 1 for UMass Chemistry 423 Spring 2015]]. Protein kinase C related kinase 1 (PRK1) is a component of Rho-GTPase, histone demethylase, '''androgen''' receptor, and histone demethylase signaling pathways and is involved in ovary and prostate cancer. A lot of PRK1 is expressed in cases of ovarian serous carcinoma.
== Disease ==
*[[Finasteride]]
 
*[[Zolinza (Vorinostat)]]
== Relevance ==
 
== Structural highlights ==
 
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.


</StructureSection>
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== References ==
== References ==
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