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'''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10''' | '''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10''' | ||
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[[Category: Erickson, H P.]] | [[Category: Erickson, H P.]] | ||
[[Category: Leahy, D J.]] | [[Category: Leahy, D J.]] | ||
[[Category: | [[Category: Extracellular matrix]] | ||
[[Category: | [[Category: Rgd]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:07 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 13:32, 2 May 2008
FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Overview
We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
About this Structure
1FNF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region., Leahy DJ, Aukhil I, Erickson HP, Cell. 1996 Jan 12;84(1):155-64. PMID:8548820 Page seeded by OCA on Fri May 2 16:32:07 2008
