3ilc: Difference between revisions
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==Crystal structure of mouse Bcl-xl mutant (Y101A) at pH 6.0== | ==Crystal structure of mouse Bcl-xl mutant (Y101A) at pH 6.0== | ||
<StructureSection load='3ilc' size='340' side='right' caption='[[3ilc]], [[Resolution|resolution]] 1.64Å' scene=''> | <StructureSection load='3ilc' size='340' side='right'caption='[[3ilc]], [[Resolution|resolution]] 1.64Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ilc]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ilc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ILC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ILC FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ihc|3ihc]], [[3iih|3iih]], [[3ihd|3ihd]], [[3ihe|3ihe]], [[3iig|3iig]], [[3ihf|3ihf]], [[3ilb|3ilb]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ihc|3ihc]], [[3iih|3iih]], [[3ihd|3ihd]], [[3ihe|3ihe]], [[3iig|3iig]], [[3ihf|3ihf]], [[3ilb|3ilb]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bcl-xl, Bcl2l, Bcl2l1, Bclx ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ilc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ilc OCA], [https://pdbe.org/3ilc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ilc RCSB], [https://www.ebi.ac.uk/pdbsum/3ilc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ilc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[B-cell lymphoma | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Hwang, K Y]] | [[Category: Hwang, K Y]] | ||
