Myosin 3D Structures

3D Structures of Myosin

Updated on 15-November-2021

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• Myosin I
  • 4byf – hMIC + calmodulin – human
    
  • 2xmf – mMI SH3 domain - mouse
    
  • 5h53 - rMI LC+HC + rActin – rabbit - Cryo EM
    
  • 1lkx, 5ejy – DdMI HC - Dictyostelium discoideum
    
  • 5ejs – DdMI HC (mutant)
    
  • 4a7f - DdMI HC + rActin + rTropomyosin – Cryo EM
    
  • 4a7h, 4a7l - DdMI HC (mutant) + rActin + rTropomyosin – Cryo EM
    
  • 6ui4 – MI + calmodulin – fungus
    
  • 5ibw – DdMIC HC + Ca-binding protein
    
  • 2drk, 2drm – MI HC + 10-mer peptide – Acanthamoeba castellanii
    
  • 6i7e, 6i7d – MI – Plasmodium falciparum
    
• Unconventional myosin I
  • 5v7x – raMIB + calmodulin – rat – Cryo EM
    
  • 6c1h, 6c1g – raMIB + calmodulin + actin – Cryo EM
    
  • 4l79 – raMIB + calmodulin
    
  • 6c1d – raMIB + calmodulin + actin + phalloidin – Cryo EM
    
  • 4r8g – mMIC C-terminal + calmodulin
    
  • 5xgg, 5xg9 – EhMIB C-terminal SH3 – Entamoeba histolytica
    
  • 6a9c – EhMIB C-terminal SH3 + FP10 peptide
    
• Myosin II
  • 2fxm, 2fxo – hMII HC S2 fragment
    
  • 2lnk – hMII HC + protein S100-A4 – NMR
    
  • 3zwh - hMII HC + protein S100-A4 (mutant)
    
  • 1o1g, 1o1a , 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o18, 1o19, 1mvw, 1m8q – cMII RLC+ELC+HC+actin – tomography - chicken
    
  • 3lla – cMII HC α-kinase domain+AMPPCP
    
  • 3lmh – cMII HC α-kinase domain+ADP
    
  • 3lmi – cMII HC α-kinase domain (mutant) +ATP
    
  • 6xe9, 6z47 - MII HC 11 + LC 9 – turkey - Cryo EM
    
  • 3i5f – LpMII RLC+HC+ADP+Mg – Loligo pealei
    
  • 3i5g, 3i5h – LpMII RLC+HC+ELC
    
  • 3i5i – LpMII RLC+HC+ELC+SO4
    
  • 2jhr – DdMII HC+ADP-VO4+pentabromopseudilin
    
  • 2xo8 - DdMII HC MD +pseudilin derivative
    
  • 2y0r, 2y8i, 2y9e, 3myk - DdMII HC MD (mutant)
    
  • 3bz7, 3bz9, 1yv3, 3bz8 - DdMII HC+blebbistatin
    
  • 3mjx - DdMII HC+blebbistatin + ADP-VO4
    
  • 3mnq - DdMII HC MD + ADP-VO4 + reservatrol
    
  • 4pjk - DdMII HC MD + ADP
    
  • 3bas, 3bat, 1fmv, 6z7t - DdMII HC
    
  • 1fmw – DdMII HC+ATP
    
  • 1jwy, 1jx2 – DdMII HC+dynamin-1
    
  • 1d0x, 1d0y, 1d0z, 1d1a, 1d1b, 1d1c – DdMII HC (mutant)+BeF3 derivative
    
  • 1g8x – DdMII+actinin 3
    
  • 2jj9, 2x9h, 7b19, 7b1a - DdMII HC+ADP-VO4
    
  • 3mkd - DdMII HC MD (mutant) + ADP-VO4
    
  • 1lvk, 1mma, 1mmg, 1mmn – DdMII HC (mutant)+Mg+nucleotide
    
  • 1myh, 1myk, 1myl, 3myh, 3myl - DdMII HC (mutant)
    
  • 1mne - DdMII HC (mutant)+Mg+pyrophosphate
    
  • 1vom - DdMII HC (truncated)+Mg+ADP-VO4
    
  • 1mmd, 1w9i, 1w9k - DdMII HC (mutant)+Mg+ADP+BeF3
    
  • 1mnd, 1w9j, 1w9l - DdMII HC (mutant)+Mg+ADP+AlF4
    
  • 2aka - DdMII HC+dynamin-1
    
  • 2xel, 4ae3 – DdMII HC + inhibitor
    
  • 6z7u - DdMII HC + ADP + blebibistatin
    
  • 6ixo – yMII GTD - yeast
    
  • 6eyw – yMII CBD
    
  • 1n2d – yMII LC+IQ2 IQ3 motifs from Myo2p
    
  • 1m45 - yMII LC+IQ2 motif from Myo2p
    
  • 1m46 - yMII LC+IQ4 motif from Myo2p
    
  • 6ixr, 6ixq, 6ixp – yMII GTD (mutant) + peptide
    
  • 2bl0 – MII RLC +RHC – Physarum polycephalum
    
  • 5w1a - MII HC MD + LC – Drosophila melanogaster
    
  • 5e4h - smMII HC kinase domain – slime mold
    
  • 5e9e - smMII HC kinase domain + AMPPNP
    
  • 7kog - wbMII HC coiled-coil domain – water bug - Cryo EM
    
• Myosin III
  • 6jle - hMIIIa tail domain + MORN4
    
  • 2btt – ScMIII SH3 domain – NMR
    
  • 1ruw, 1va7 – yMIII SH3 domain
• Myosin IV
  • 6ysy - rMV HC+LC+Mg-ADP-VO4
    
  • 7nep - mMV HC+LC + actin + tropomyocin – Cryo EM
    
  • 3mmi – yMIV GTD
    
  • 4ll6 - yMIV GTD (mutant)
    
  • 4ll8 - yMIV GTD (mutant) + SHE3P
    
  • 6qdj – MIV – Caenorhabditis elegans
    
• Myosin V (Unconventional myosin)
  • 4lx1 – hMVA GTD
    
  • 4lx2 – hMVA GTD + melanphilin
    
  • 5jcz – hMVA GTD + RAB-11
    
  • 5jcy – hMVA GTD + SPIR-2
    
  • 4lnz – hMVB GTD
    
  • 4lwz, 4lx0 – hMVB GTD + RAS-related protein
    
  • 5hmp, 4zg4 – hMVC
    
  • 4l8t – hMVC CBD
    
  • 4j5l, 4j5m – hMVA GTD
    
  • 4zlk - mMVA + calmodulin
    
  • 2ix7 – mMVA IQ motif +apo-calmodulin
    
  • 3wb8 – mMVA GTD
    
  • 4kp3 – mMVA GTD + RILP-like protein + melanophilin
    
  • 1w7i – cMV HC+LC+Mg+ADP
    
  • 1w7j - cMV HC+LC+BEFX+ADP
    
  • 1w8j – cMV HC
    
  • 1oe9 – cMV HC+LC
    
  • 1br2 – cMV HC+Mg+ADP+AlF4
    
  • 2fcd – yMV LC N-terminal – yeast – NMR
    
  • 2fce – yMV LC C-terminal – NMR
    
  • 2f6h – yMV CBD
    
  • 1yp5, 1zuy – yMV SH3 domain
    
• Myosin VI
  • 4e7z, 4pk4, 4pjn, 4pjm - pMVI
    
  • 4e7s - pMVI (mutant)
    
  • 3gn4, 2vb6 - pMVI neck+calmodulin – pig
    
  • 2vas, 3l9i - pMVI neck (mutant)+calmodulin
    
  • 2v26 - pMVI neck+Mg+ADP-VO4
    
  • 2bkh, 2bki – pMVI HC+calmodulin
    
  • 4dbp, 4dbq – pMVI HC (mutant) + calmodulin
    
  • 4dbr – pMVI HC (mutant)
    
  • 4anj - pMVI HC/GFP + calmodulin
    
  • 2x51 - pMVI d insert1 + calmodulin
    
  • 6bnw, 6bnq, 6bnp – pMVI + actin – Cryo EM
    
  • 6bnv – pMVI + actin + calmodulin – Cryo EM
    
  • 2kia – mMVI CBD – mouse – NMR
    
  • 2ld3 – mMVI lever arm extension - NMR
    
  • 3h8d - mMVI CBD+Dab2 peptide
    
  • 6obi – MVI – Meriones unguiculatus
    
• Unconventional myosin VI
  • 6j56 – hMVI CBD + TOM1 peptide
    
  • 4pfp, 4pfo, 5o2l – pMVI MD
    
  • 4pjl – pMVI MD (mutant)
    
  • 4pjj – pMVI MD + calmodulin
    
  • 5v6h – mMVI + GIPC2
    
  • 5v6e – mMVI + GIPC1
    
• Myosin VII
  • 4db1 – hMVII HC
    
  • 5n6a – bMVII HC
    
  • 5tby – bMVII HC + MIII LC + MLC-2V
    
  • 6fsa, 5n69 – bMVII HC + MIII LC
    
  • 6x5z – bMVII + cActin + hTropomyosin – Cryo EM
    
  • 7jh7 - pMVII HC + actin + tropomyocin – Cryo EM
    
  • 3pvl - mMVII SH3 domain+hUsher syndrome type 1G protein
    
  • 2i0n - DdMVII SH3 domain - NMR
    
• Unconventional myosin VII
  • 5mv7 – hMVIIB C-terminal
    
  • 5xbf, 5mv8 – hMVIIB C-terminal + harmonin
    
  • 5mv9 – hMVIIA C-terminal + harmonin
    
  • 5wsv – hMVIIA IQ5 + calmodulin
    
  • 5wsu – hMVIIA IQ5-SAH + calmodulin
    
  • 5wst – mMVIIA SAH
    
  • 5f3y – mMVIIB + ANKS4B
    
  • 5ejr – DdMVIIB MF2 domain
    
  • 5ejq – DdMVIIB MF1 domain (mutant)
    
• Unconventional myosin IX
  • 5c5s – hMIXB RHOGAP domain
    
  • 5hpy – hMIXB MD + RHOA
    
• Myosin X
  • 2lw9 - hMX
    
  • 3au5 - hMX myth4-ferm tandem
    
  • 3pzd, 3au4 - hMX myth4-ferm tandem + netrin receptor DCC
    
  • 3tfm – raMX phin-ph2-phic tandem (mutant)
• Unconventional myosin X
  • 5i0h – hMX MD
    
  • 5kg8 – hMX MD + actin
    
  • 5i0i – hMX MD + calmodulin
    
  • 5hmo – MX SAH + coiled-coil domain - bovine
    
• Myosin XI
  • 5t45 – cMXI MD
    
  • 5m05 – cMXI MD + inhibitor
    
  • 3j04 – cMXI HC + RLC – Cryo EM
    
  • 6bih – cMXI HC + actin – Cryo EM
    
• Unconventional myosin XI
  • 7kch – cMXI + actin + ADP – Cryo EM
    
  • 7dhw – AtMXI MD + ADP - Arabidopsis thaliana
    
• Myosin XIV
  • 5jlh – hMIV/actinin + actin + tropomyocin + ADP – Cryo EM
    
• Unconventional myosin XIV or myosin-A
  • 6due – TgMXIV – Toxoplasma gondii
    
  • 6tj5, 6tj6, 6tj7 – TgMIV ELC + calmodulin
    
  • 6i7d – PfMI – Plasmodium falciparum
    
  • 6tj4 – PfMIV ELC N-terminal
    
  • 6tj3 – PfMIV ELC N-termina - NMRl
    
  • 6i7e, 6ycx, 6ycy, 6ycz – PfMI + ADP
    
  • 6zn3 – PfMIV ELC + myosin A tail end interacting protein
    
  • 6tu7 – PfMIV + actin + ADP – Cryo EM
    
  • 7aln – PfMIV (mutant) + actin – Cryo EM
    
• Unconventional myosin XV
  • 7r91, 7rb8, 7rb9 – mMXV + actin + ADP – Cryo EM
    
• Myosin XVII
  • 7kfl – AtMXVII CBD
    
• Flight muscle myosin
  • 1i84, 2w4a, 2w4g, 2w4h - cRLC+cELC+cHC – cryoEM
    
  • 2mys - cRLC+cELC+cHC - papain digested
    
  • 1lkm – cHC alpha-kinase domain+AMP
    
  • 2dfs – cHC+calmodulin
    
  • 1br4 – cELC+cHC+Mg+ADP+BeF3
    
  • 1br1 – cELC+Mg+ADP+AlF4
    
  • 3jtd, 2w4t, 2w4v, 2w4w, 1scm – AiRLC+AiELC+AiHC - Argopecten irradians
    
  • 1b7t - AiRLC+AiELC+AiHC papain digested
    
  • 3jvt - sRLC+sELC+sHC+Ca – Scallop
    
  • 2ec6, 2os8, 2otg, 1s5g, 1sr6, 1qvi, 1kk7, 1dfk, 3pn7, 3ts5, 3tuy - sRLC+sELC+sHC
    
  • 1kqm - sRLC+sELC+sHC+AMPPNP
    
  • 1kwo - sRLC+sELC+sHC+ATPgS-PDM
    
  • 1l2o - sRLC+sELC+sHC+ADP-PDM
    
  • 1kk8 - sRLC+sELC+sHC+ADP-BEFX
    
  • 1dfl - sRLC+sELC+sHC+ADP-VO4+Mg
    
  • 1wdc - sRLC+sELC+sHC - digested
    
  • 3dtp - RLC+HC+ELC – tarantula – Cryo EM
    
  • 6so3 - wbRLC+HC+ELC – Cryo EM
    

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Michal Harel