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| *Netrin-1 | | *Netrin-1 |
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| | **[[7ne1]] – hNet1 V-VI domains 39-453 + neogenin - human<BR /> |
| | **[[7ne0]] – hNet1 V-VI domains + neogenin + RGMB<BR /> |
| | **[[7ndg]] – hNet1 V-VI domains + neogenin + RGMB – Cryo EM<BR /> |
| | **[[4urt]] – hNet1 V-VI domains + hNet receptor DCC fourth fibronectin type FN5-FN6 domains <BR /> |
| | **[[6fkq]] – hNet1 V-VI domains + draxin peptide<BR /> |
| **[[4ove]] – mNet1 – mouse<BR /> | | **[[4ove]] – mNet1 – mouse<BR /> |
| **[[4plm]] – cNet1 LN-LE3 domains – chicken<BR /> | | **[[4plm]] – cNet1 LN-LE3 domains – chicken<BR /> |
| **[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br /> | | **[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br /> |
| **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | | **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> |
| **[[4urt]] – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human<BR />
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| **[[6fkq]] – hNet1 LN-LE3 domains + draxin peptide<BR />
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| *Netrin-4 | | *Netrin-4 |
Revision as of 10:03, 17 November 2021
| Function
Netrins (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types[1]. Netrin-1 is a secreted protein while netrin-G2 is GPI-anchored membrane protein.
Relevance
Netrin-1 is over-expressed in glioblastoma tumor[2]. Netrin-1 is a therapeutic target in cardiovascular diseases[3].
Structural highlights
The N-terminal of netrin-1 is homologous to the N-terminal type I domain of laminin (LN) followed by 3 cysteine-rich epidermal growth factor repeats.
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:https://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Ylivinkka I, Hu Y, Chen P, Rantanen V, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiainen M. Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion. J Cell Sci. 2013 Jun 1;126(Pt 11):2459-69. doi: 10.1242/jcs.120022. Epub 2013 Apr, 2. PMID:23549787 doi:https://dx.doi.org/10.1242/jcs.120022
- ↑ Layne K, Ferro A, Passacquale G. Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit? Cardiovasc Res. 2015 Sep 1;107(4):410-9. doi: 10.1093/cvr/cvv201. Epub 2015 Jul, 24. PMID:26209250 doi:https://dx.doi.org/10.1093/cvr/cvv201
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3D Structures of netrin
Updated on 17-November-2021
{"openlevels":0}
- Netrin-1
- 7ne1 – hNet1 V-VI domains 39-453 + neogenin - human
- 7ne0 – hNet1 V-VI domains + neogenin + RGMB
- 7ndg – hNet1 V-VI domains + neogenin + RGMB – Cryo EM
- 4urt – hNet1 V-VI domains + hNet receptor DCC fourth fibronectin type FN5-FN6 domains
- 6fkq – hNet1 V-VI domains + draxin peptide
- 4ove – mNet1 – mouse
- 4plm – cNet1 LN-LE3 domains – chicken
- 4pln – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains
- 4plo – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains
- Netrin-4
- Netrin-G1
- 3zyj – hNetG1 LAM + EGF1 domains (mutant) + leucine-rich repeat-containing protein
- Netrin-G2
- 3tbd – hNetG2 VI + LE1 domains
- 3zyg – hNetG2 LAM + EGF1 domains
- 3zyi – hNetG2 LAM + EGF1 domains + leucine-rich repeat-containing protein
References
