6x6y: Difference between revisions
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==Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1264== | ==Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1264== | ||
<StructureSection load='6x6y' size='340' side='right'caption='[[6x6y]]' scene=''> | <StructureSection load='6x6y' size='340' side='right'caption='[[6x6y]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X6Y FirstGlance]. <br> | <table><tr><td colspan='2'>[[6x6y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X6Y FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x6y OCA], [https://pdbe.org/6x6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x6y RCSB], [https://www.ebi.ac.uk/pdbsum/6x6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x6y ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=USY:N-[4-(4-fluorophenyl)-4-oxobutyl]guanidine'>USY</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">eis, Rv2416c, MTCY253.04 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x6y OCA], [https://pdbe.org/6x6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x6y RCSB], [https://www.ebi.ac.uk/pdbsum/6x6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x6y ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/EIS_MYCTU EIS_MYCTU]] May participate in pathogenesis, possibly by enhancing survival of the bacteria in host macrophages during infection.<ref>PMID:10629183</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Garneau-Tsodikova S]] | [[Category: Myctu]] | ||
[[Category: Punetha A]] | [[Category: Garneau-Tsodikova, S]] | ||
[[Category: Tsodikov | [[Category: Punetha, A]] | ||
[[Category: Tsodikov, O V]] | |||
[[Category: Acetylation]] | |||
[[Category: Aminoglycoside]] | |||
[[Category: Drug resistance]] | |||
[[Category: Inhibitor]] | |||
[[Category: Repurposing]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 12:41, 24 November 2021
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1264
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