2b9e: Difference between revisions

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<StructureSection load='2b9e' size='340' side='right'caption='[[2b9e]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='2b9e' size='340' side='right'caption='[[2b9e]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2b9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B9E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2b9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9e OCA], [http://pdbe.org/2b9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b9e RCSB], [http://www.ebi.ac.uk/pdbsum/2b9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9e OCA], [https://pdbe.org/2b9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9e RCSB], [https://www.ebi.ac.uk/pdbsum/2b9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/NSUN5_HUMAN NSUN5_HUMAN]] NSUN5 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.  
[[https://www.uniprot.org/uniprot/NSUN5_HUMAN NSUN5_HUMAN]] NSUN5 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NSUN5_HUMAN NSUN5_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA.  
[[https://www.uniprot.org/uniprot/NSUN5_HUMAN NSUN5_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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