Transmembrane protease serine 2: Difference between revisions
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=== Gene === | === Gene === | ||
The ''TMPRSS2'' gene resides on chromosome 21 at the band 21q22.3, and is split into | The ''TMPRSS2'' gene resides on chromosome 21 at the band 21q22.3, extends aproximately 43.59 kb and is split into 14 exons. | ||
This gene is conserved in a wide variety of animals, such as chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, ''Caenorhabditis elegans'' and frog. | This gene is conserved in a wide variety of animals, such as chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, ''Caenorhabditis elegans'' and frog. | ||
This gene presents two alternative splicing variants resulting in a 3.25 kb and 3.21 kb transcripts, respectively. | |||
=== Protein === | === Protein === | ||
TMPRSS2 is a 492 amino acid single-pass type II membrane protein. This protein is defined by the presence of an N-terminal cytoplasmic domain, a transmembrane helical domain, and three extracellular domains: <ref>DOI 10.1136/jclinpath-2020-206987</ref> | |||
*Low-density lipoprotein (LDL)-receptor class A domain | *Low-density lipoprotein (LDL)-receptor class A domain: which forms a binding site for calcium | ||
*Scavenger receptor cysteine-rich domain (SRCR) | *Scavenger receptor cysteine-rich domain (SRCR) | ||
*Peptidase S1 domain, also known as serine protease domain (SPD) | *Peptidase S1 domain, also known as serine protease domain (SPD) | ||
