Transmembrane protease serine 2: Difference between revisions
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==== Camostat mesylate ==== | ==== Camostat mesylate ==== | ||
==== Bromhexine ==== | ==== Bromhexine ==== | ||
Bromhexine hydrochloride (BHH) is an ingredient in a mucolytic cough suppressant that inhibits TMPRSS2. It has been proposed | |||
effectively attenuates | |||
prostate cancer metastasis in mice. | |||
Repurposing of the mucolytic agent called bromhexine, a TMPRSS2 inhibitor, has been also proposed for COVID-19 therapy.<ref>DOI 10.1016/j.phrs.2020.104837</ref> | Repurposing of the mucolytic agent called bromhexine, a TMPRSS2 inhibitor, has been also proposed for COVID-19 therapy.<ref>DOI 10.1016/j.phrs.2020.104837</ref> | ||
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a mucolytic cough suppressant that also effectively attenuates | a mucolytic cough suppressant that also effectively attenuates | ||
prostate cancer metastasis in mice. Furthermore, it shows specific | prostate cancer metastasis in mice. Furthermore, it shows specific | ||
inhibition of TMPRSS2 (IC50 ¼ 0.75 mM). Given that BHH is an | inhibition of TMPRSS2 (IC50 ¼ 0.75 mM). Given that BHH is an FDA approved drug with no significant adverse effects, it could be used | ||
for treatment of influenza virus and coronavirus infections as an | for treatment of influenza virus and coronavirus infections as an | ||
inhibitor of TMPRSS2. | inhibitor of TMPRSS2. | ||
