2cky

Structure of the Arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand

spinqualitylabelsall models 2cky, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2cky is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG, OS, TPP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine. Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand.,Thore S, Leibundgut M, Ban N Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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