Transmembrane protease serine 2: Difference between revisions
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TMPRSS2 (Transmembrane protease serine 2) is a membrane protein belonging to the '''type II transmembrane serine protease (TTSP) family'''. It is functionally classified as a '''trypsin-like protease''' (TLP). <ref>DOI 10.3389/fmolb.2021.666626</ref> Serine proteases are known to be involved in many physiological and pathological processes, but the exact function remains | TMPRSS2 (Transmembrane protease serine 2) is a membrane protein belonging to the '''type II transmembrane serine protease (TTSP) family'''. It is functionally classified as a '''trypsin-like protease''' (TLP). <ref>DOI 10.3389/fmolb.2021.666626</ref> Serine proteases are known to be involved in many physiological and pathological processes, but the exact function remains unclear. It is involved in two main pathological processes, prostate cancer and viral entry. TMPRSS2 is expressed in several tissues regulated by androgens and undergoes autocatalytic cleavage for its activation. | ||
<StructureSection load='7meq' size='340' side='right' caption='Crystal structure of human TMPRSS2 in complex with Nafamostat' scene='89/897681/Colors/1'> | <StructureSection load='7meq' size='340' side='right' caption='Crystal structure of human TMPRSS2 in complex with Nafamostat' scene='89/897681/Colors/1'> | ||
