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| Line 31: |
Line 31: |
| *α-parvalbumin | | *α-parvalbumin |
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| **[[5pal]] – PVA-α - shark<br /> | | **[[1rjv]], [[1rk9]] - hPVA-α - human – NMR<br /> |
| **[[1rtp]], [[1rwy]] - rPVA-α - rat<br /> | | **[[1rtp]], [[1rwy]] - rPVA-α - rat<br /> |
| **[[2jww]] - rPVA-α Ca-free – NMR<br /> | | **[[2jww]] - rPVA-α Ca-free – NMR<br /> |
| **[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br /> | | **[[1g33]], [[1s3p]], [[1xvj]], [[3f45]] - rPVA-α (mutant)<br /> |
| **[[1rjv]], [[1rk9]] - hPVA-α - human – NMR | | **[[5pal]] – PVA-α - shark<br /> |
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| *β-parvalbumin (oncomodulin) | | *β-parvalbumin (oncomodulin) |
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| | **[[1ttx]] - hPVA-β (mutant) – NMR<br /> |
| **[[2nln]] - rPVA-β Ca-free – NMR<br /> | | **[[2nln]] - rPVA-β Ca-free – NMR<br /> |
| **[[1rro]], [[1omd]] - rPVA-β <br /> | | **[[1rro]], [[1omd]] - rPVA-β <br /> |
| **[[1ttx]] - hPVA-β (mutant) – NMR<br />
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| **[[3fs7]] - chPVA-β - chicken<br /> | | **[[3fs7]] - chPVA-β - chicken<br /> |
| **[[2kqy]] – chPVA-β – NMR<br /> | | **[[2kqy]] – chPVA-β – NMR<br /> |
| Function
Parvalbumin (PVA) is a calcium-binding albumin protein. PVA is involved in calcium signaling[1]. PVA contains 3 domains each containing 2 helices: AB, CD (N-terminal) and EF (C-terminal). α-parvalbumin differs from β-parvalbumin in 54 positions. α-parvalbumin is expressed in various tissues while β-parvalbumin is expressed only in preterm placenta[2].
See also
Relevance
PVA is a major fish allergen[3].
Structural highlights
PVA contains a heptacoordinated Ca+2 ion binding to 7 oxygen atoms in a typical EF-hand coordination[4]. Water molecules are shown as red spheres. Calcium ion is coordinated by seven oxygen atoms that form a pentagonal bipyramid .
- ↑ Cates MS, Teodoro ML, Phillips GN Jr. Molecular mechanisms of calcium and magnesium binding to parvalbumin. Biophys J. 2002 Mar;82(3):1133-46. PMID:11867433 doi:https://dx.doi.org/10.1016/S0006-3495(02)75472-6
- ↑ Fohr UG, Weber BR, Muntener M, Staudenmann W, Hughes GJ, Frutiger S, Banville D, Schafer BW, Heizmann CW. Human alpha and beta parvalbumins. Structure and tissue-specific expression. Eur J Biochem. 1993 Aug 1;215(3):719-27. PMID:8354278
- ↑ Lim DL, Neo KH, Yi FC, Chua KY, Goh DL, Shek LP, Giam YC, Van Bever HP, Lee BW. Parvalbumin--the major tropical fish allergen. Pediatr Allergy Immunol. 2008 Aug;19(5):399-407. doi:, 10.1111/j.1399-3038.2007.00674.x. Epub 2008 Jan 25. PMID:18221468 doi:https://dx.doi.org/10.1111/j.1399-3038.2007.00674.x
- ↑ Declercq JP, Evrard C, Lamzin V, Parello J. Crystal structure of the EF-hand parvalbumin at atomic resolution (0.91 A) and at low temperature (100 K). Evidence for conformational multistates within the hydrophobic core. Protein Sci. 1999 Oct;8(10):2194-204. PMID:10548066
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3D Structures of Parvalbumin
Updated on 05-December-2021
{"openlevels":0}
- parvalbumin
- EF hand, Parvalbumin carp – cPVA - carp
- 1cdp – cPVA Cd-substituted
- 1b8c, 1b8r, 1b9a, 1b8l – cPVA (mutant)
- 1pal, 2pal, 3pal, 4pal, 1pvb, 1pva, 2pvb – pPVA – pike
- 2pas, 3pat – pPVA – NMR
- 1a75 – PVA – whiting
- 1bu3 – PVA Ca-binding domain – hake
- 5zgm – MgPVA SPV-I – Mustelus griseus
- 5zh6 – MgPVA SPV-II
- α-parvalbumin
- β-parvalbumin (oncomodulin)
- 1ttx - hPVA-β (mutant) – NMR
- 2nln - rPVA-β Ca-free – NMR
- 1rro, 1omd - rPVA-β
- 3fs7 - chPVA-β - chicken
- 2kqy – chPVA-β – NMR
- 2kyc - chPVA-β
- 2kyf - chPVA-β (mutant) – NMR
- 2mbx - PVA-β – cod - NMR
- 5xnd - PVA-β – mackerel - NMR
References
