Sandbox Reserved 1697: Difference between revisions

@@ Line 12: / Line 12: @@
 == Important amino acids==
-In the protein seen in the paper there is a mutation at residue 54, causing an <scene name='89/892740/Mutation_scence/1'>aspartic acid to change to an alanine</scene>. The catalytic amino acids are <scene name='89/892740/Catalytic_amino_acids/1'>Thr 312, Lys 270, Ser 268, Glu 269, Ser 157, Asp 156, Thr 158, Ala 291, Lys 294, and Thr 313</scene>.
+In this protein the amino acids do not interact with the substrate itself, instead they interact with the metal ions. When magnesium is present, and the protein therefore activated, the amino acids will hold onto the magnesium ions. These magnesium ions that interact with the inositol and water so that it can dephosphorylate the substrate. The motif of enzymes in this family is DPIDXT. In this particular protein the motif is <scene name='89/892740/Motif_view/1'>D54, E80, E79, D153, and D317</scene>. There are some mutations in the enzyme but the overall function of the protein is still the same.
 == Structural highlights ==

Navigation menu