6kle: Difference between revisions

<table><tr><td colspan='2'>[[6kle]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Machu Machu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KLE FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kle OCA], [http://pdbe.org/6kle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kle RCSB], [http://www.ebi.ac.uk/pdbsum/6kle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kle ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/Q6IVU0_MACHU Q6IVU0_MACHU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836]