7lyj: Difference between revisions
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==SARS-CoV-2 frameshifting pseudoknot RNA== | ==SARS-CoV-2 frameshifting pseudoknot RNA== | ||
<StructureSection load='7lyj' size='340' side='right'caption='[[7lyj]]' scene=''> | <StructureSection load='7lyj' size='340' side='right'caption='[[7lyj]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7lyj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyj OCA], [https://pdbe.org/7lyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyj RCSB], [https://www.ebi.ac.uk/pdbsum/7lyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyj ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyj OCA], [https://pdbe.org/7lyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyj RCSB], [https://www.ebi.ac.uk/pdbsum/7lyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyj ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 A-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome, and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics. | |||
Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.,Jones CP, Ferre-D'Amare AR RNA. 2021 Nov 29. pii: rna.078825.121. doi: 10.1261/rna.078825.121. PMID:34845084<ref>PMID:34845084</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7lyj" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ferre-D | [[Category: Amare, A R.Ferre-D]] | ||
[[Category: Jones | [[Category: Jones, C P]] | ||
[[Category: Coronavirus]] | |||
[[Category: Covid]] | |||
[[Category: Frameshift]] | |||
[[Category: Pseudoknot]] | |||
[[Category: Rna]] | |||
[[Category: Sar]] | |||
[[Category: Severe acute respiratory syndrome]] | |||
[[Category: Tetraloop]] | |||
[[Category: Triple]] | |||
[[Category: Virus]] | |||
Revision as of 10:07, 8 December 2021
SARS-CoV-2 frameshifting pseudoknot RNA
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