2dnu: Difference between revisions

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<StructureSection load='2dnu' size='340' side='right'caption='[[2dnu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2dnu' size='340' side='right'caption='[[2dnu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dnu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DNU FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnu OCA], [http://pdbe.org/2dnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dnu RCSB], [http://www.ebi.ac.uk/pdbsum/2dnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnu ProSAT], [http://www.topsan.org/Proteins/RSGI/2dnu TOPSAN]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnu OCA], [https://pdbe.org/2dnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dnu RCSB], [https://www.ebi.ac.uk/pdbsum/2dnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dnu ProSAT], [https://www.topsan.org/Proteins/RSGI/2dnu TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN]] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref>   
[[https://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN]] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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