2zg2: Difference between revisions
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==Crystal Structure of Two N-terminal Domains of Native Siglec-5== | ==Crystal Structure of Two N-terminal Domains of Native Siglec-5== | ||
<StructureSection load='2zg2' size='340' side='right' caption='[[2zg2]], [[Resolution|resolution]] 2.85Å' scene=''> | <StructureSection load='2zg2' size='340' side='right'caption='[[2zg2]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zg2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2zg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZG2 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o7s|1o7s]], [[1qfo|1qfo]], [[1nko|1nko]], [[2df3|2df3]], [[2g5r|2g5r]], [[2hrl|2hrl]], [[2zg1|2zg1]], [[2zg3|2zg3]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o7s|1o7s]], [[1qfo|1qfo]], [[1nko|1nko]], [[2df3|2df3]], [[2g5r|2g5r]], [[2hrl|2hrl]], [[2zg1|2zg1]], [[2zg3|2zg3]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIGLEC5 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIGLEC5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zg2 OCA], [https://pdbe.org/2zg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zg2 RCSB], [https://www.ebi.ac.uk/pdbsum/2zg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zg2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/SIGL5_HUMAN SIGL5_HUMAN]] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/2zg2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/2zg2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Sun, P D]] | [[Category: Sun, P D]] | ||
[[Category: Zhuravleva, M A]] | [[Category: Zhuravleva, M A]] | ||
