Fel d 1: Difference between revisions
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The major allergen in cats, [[Fel d 1]], belongs to the [https://en.wikipedia.org/wiki/Secretoglobin secretoglobin] family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces [https://www.ncbi.nlm.nih.gov/books/NBK27117/ IgE] responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE [https://en.wikipedia.org/wiki/Epitope#T_cell_epitopes epitopes] on the surface of the protein <ref name="[1]"> PMID: 12851385 </ref>. | The major allergen in cats, [[Fel d 1]], belongs to the [https://en.wikipedia.org/wiki/Secretoglobin secretoglobin] family of proteins and is, worldwide, one of the major causes of allergic asthma, as it induces [https://www.ncbi.nlm.nih.gov/books/NBK27117/ IgE] responses in 90 to 95% of those allergic to cats and in 60 to 90% of total allergenic activity to cat hair. Symptoms range from mild rhinitis and conjunctivitis to life-threatening asthmatic responses. The structure of Fel d 1 displays the location of three previously defined Fel d 1 IgE [https://en.wikipedia.org/wiki/Epitope#T_cell_epitopes epitopes] on the surface of the protein <ref name="[1]"> PMID: 12851385 </ref>. | ||
It is produced mainly by the salivary and sebaceous glands, it is also present in the perianal, lacrimal and squamous epithelial cells and is attached to the cat's hair through the habit of licking <ref name="[1]"/><ref name="[3]">WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.</ref>. | It is produced mainly by the salivary and sebaceous glands, it is also present in the perianal, lacrimal and squamous epithelial cells and is attached to the cat's hair through the habit of licking <ref name="[1]"/><ref name="[3]">WANDALSEN, Gustavo Falbo; SANO, Flavio; SOLÉ, Dirceu. Alérgenos do gato nas alergias respiratórias: situação atual e novas perspectivas. Asma, alergia e imunologia, São Paulo, SP, Brasil, v. 4, n. 1, p. 61-71, 10 mar. 2020. doi: http://dx.doi.org/10.5935/2526-5393.20200004.</ref>. | ||
In the 3D scene of the asymmetric unit of Fel d 1 it is possible to <scene name="/12/3456/Sample/1">color</scene> by group, make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein Fel d 1 and visualize four [http://www.chemspider.com/Chemical-Structure.13884973.html MPD] molecules (used in the crystallization of Fel d 1) <ref name="[1]"/> <ref>DOI 10.1002/ijch.201300024</ref> <ref>PMID:21638687</ref>. | |||
== '''Function''' == | == '''Function''' == | ||
The biological function of Fel d 1 is still unknown, however it is thought to have a pheromone/chemical signaling function<ref name="[3]"/>. | The biological function of Fel d 1 is still unknown, however it is thought to have a pheromone/chemical signaling function<ref name="[3]"/>. | ||
== '''Structure''' == | == '''Structure''' == | ||
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[[Image:Cavidades e Zoom.png | thumb | center | 700px | '''Figure 4.''' Shape of the cavities (in gray) directly governed by the conformation of Leu129 and Asp130 residues. The Asp130 side chain (underlined) does not interact with Ca<sup>2+</sup> and projects into the cavity in the A subunit (in cyan), while the Asp130 side chain (B subunit) binds to Ca<sup>2+</sup>. These conformations can be seen in ampliation. The Ca<sup>2+</sup> ions are also indicated like red balls. (Source: PyMOL 2.5.2)]] | [[Image:Cavidades e Zoom.png | thumb | center | 700px | '''Figure 4.''' Shape of the cavities (in gray) directly governed by the conformation of Leu129 and Asp130 residues. The Asp130 side chain (underlined) does not interact with Ca<sup>2+</sup> and projects into the cavity in the A subunit (in cyan), while the Asp130 side chain (B subunit) binds to Ca<sup>2+</sup>. These conformations can be seen in ampliation. The Ca<sup>2+</sup> ions are also indicated like red balls. (Source: PyMOL 2.5.2)]] | ||
Figure 5 shows the three-dimensional configuration of Fel d 1. | Figure 5 shows the three-dimensional configuration of Fel d 1. | ||
