7dkn: Difference between revisions
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==Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase== | ==Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase== | ||
<StructureSection load='7dkn' size='340' side='right'caption='[[7dkn]]' scene=''> | <StructureSection load='7dkn' size='340' side='right'caption='[[7dkn]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DKN FirstGlance]. <br> | <table><tr><td colspan='2'>[[7dkn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DKN FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dkn OCA], [https://pdbe.org/7dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dkn RCSB], [https://www.ebi.ac.uk/pdbsum/7dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dkn ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dkn OCA], [https://pdbe.org/7dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dkn RCSB], [https://www.ebi.ac.uk/pdbsum/7dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dkn ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity). | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Iizuka Y]] | [[Category: Iizuka, Y]] | ||
[[Category: Kikuchi M]] | [[Category: Kikuchi, M]] | ||
[[Category: Tsunoda M]] | [[Category: Tsunoda, M]] | ||
[[Category: Yamauchi T]] | [[Category: Yamauchi, T]] | ||
[[Category: Methyltransferase]] | |||
[[Category: Transferase]] | |||
Revision as of 16:56, 15 December 2021
Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase
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