1fzb: Difference between revisions
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'''CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D''' | '''CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D''' | ||
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[[Category: Everse, S J.]] | [[Category: Everse, S J.]] | ||
[[Category: Spraggon, G.]] | [[Category: Spraggon, G.]] | ||
[[Category: | [[Category: Blood coagulation]] | ||
[[Category: | [[Category: Fibrin]] | ||
[[Category: | [[Category: Fibrinogen]] | ||
[[Category: | [[Category: Plasma]] | ||
[[Category: | [[Category: Platelet]] | ||
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Revision as of 13:56, 2 May 2008
CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D
Overview
In blood coagulation, units of the protein fibrinogen pack together to form a fibrin clot, but a crystal structure for fibrinogen is needed to understand how this is achieved. The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 A resolution. The 86K three-chained structure consists of a coiled-coil region and two homologous globular entitles oriented at approximately 130 degrees to each other. Additionally, the covalently bound dimer of fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by molecular replacement with the model of fragment D.
About this Structure
1FZB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin., Spraggon G, Everse SJ, Doolittle RF, Nature. 1997 Oct 2;389(6650):455-62. PMID:9333233 Page seeded by OCA on Fri May 2 16:56:05 2008
