Sandbox Reserved 1091: Difference between revisions
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Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factor than promote their pathogenicity. | Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factor than promote their pathogenicity. | ||
The nonintestinal form of the disease reports symptoms such as [http://en.wikipedia.org/wiki/Sepsis septicemia], lesions of skin and soft tissues as well as [ | The nonintestinal form of the disease reports symptoms such as [http://en.wikipedia.org/wiki/Sepsis septicemia], lesions of skin and soft tissues as well as [https://bio.libretexts.org/Bookshelves/Microbiology/Book%3A_Microbiology_(Boundless)/15%3A_Diseases/15.4%3A_Microbial_Diseases_of_the_Nervous_System/15.4C%3A_Meningitis meningitis], often ending fatally. That leads to a crucial reduction in tissue perfusion followed by fatal organ disfunction. | ||
The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation. | The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation. | ||