Sandbox Reserved 1091: Difference between revisions

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Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factor than promote their pathogenicity.  
Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factor than promote their pathogenicity.  


The nonintestinal form of the disease reports symptoms such as [http://en.wikipedia.org/wiki/Sepsis septicemia], lesions of skin and soft tissues as well as [http://en.wikipedia.org/wiki/Meningitis meningitis], often ending fatally. That leads to a crucial reduction in tissue perfusion followed by fatal organ disfunction.  
The nonintestinal form of the disease reports symptoms such as [http://en.wikipedia.org/wiki/Sepsis septicemia], lesions of skin and soft tissues as well as [https://bio.libretexts.org/Bookshelves/Microbiology/Book%3A_Microbiology_(Boundless)/15%3A_Diseases/15.4%3A_Microbial_Diseases_of_the_Nervous_System/15.4C%3A_Meningitis meningitis], often ending fatally. That leads to a crucial reduction in tissue perfusion followed by fatal organ disfunction.  


The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation.  
The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation.