Sandbox Reserved 1647: Difference between revisions

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==Introduction==

TBX21 (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. The DNA binding domain of T-bet has a dimer structure ~~composes~~ of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Link_to_2_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop.

TBX21 (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. The DNA binding domain of T-bet has a dimer structure composed of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Link_to_2_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop.

The main function of this transcription factor is to direct [https://en.wikipedia.org/wiki/T_helper_cell TH1 cells differentiation] from naive CD4+ cells. Nevertheless, the action field of T-bet is larger than classical T-box protein.

Sandbox Reserved 1647: Difference between revisions

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 <Structure load='5t1j' size='350' frame='true' align='right' caption='TBX21 on two DNA' scene='86/868180/Tbx21_on_dna/1' />
 ==Introduction==
-TBX21 (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. The DNA binding domain of T-bet has a dimer structure composes of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Link_to_2_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop.
+TBX21 (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. The DNA binding domain of T-bet has a dimer structure composed of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Link_to_2_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop.
 The main function of this transcription factor is to direct [https://en.wikipedia.org/wiki/T_helper_cell TH1 cells differentiation] from naive CD4+ cells. Nevertheless, the action field of T-bet is larger than classical T-box protein.