Sandbox Reserved 1652: Difference between revisions
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Capsaicin maintains TRPV1 in an open state by «pull and contact» interactions. A conformational change wave spread over the whole pore.<ref>F. Yang et al., « The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel », Nat. Commun., vol. 9, no 1, Art. no 1, juill. 2018, doi: 10.1038/s41467-018-05339-6.</ref>. | Capsaicin maintains TRPV1 in an open state by «pull and contact» interactions. A conformational change wave spread over the whole pore.<ref>F. Yang et al., « The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel », Nat. Commun., vol. 9, no 1, Art. no 1, juill. 2018, doi: 10.1038/s41467-018-05339-6.</ref>. | ||
Capsaicin maintains TRPV1 in an open state. A conformational change wave spread over the whole pore.<ref>F. Yang et al., « The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel », Nat. Commun., vol. 9, no 1, Art. no 1, juill. 2018, doi: 10.1038/s41467-018-05339-6.</ref>. This leads to the massive enter of Ca2+ and Na+ and the depolarization of the nerve fiber. Depolarization triggers the generation of an [https://en.wikipedia.org/wiki/Action_potential action potential] causing a painful sensation.<ref name="TRPV1"/> | Capsaicin maintains TRPV1 in an open state. A conformational change wave spread over the whole pore.<ref>F. Yang et al., « The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel », Nat. Commun., vol. 9, no 1, Art. no 1, juill. 2018, doi: 10.1038/s41467-018-05339-6.</ref>. This leads to the massive enter of Ca2+ and Na+ and the depolarization of the nerve fiber. Depolarization triggers the generation of an [https://en.wikipedia.org/wiki/Action_potential action potential] causing a painful sensation.<ref name="TRPV1"/> Ca2+ has a negative retrospection effect on TRPV1 and induces a desensitization of this receptor facing capsaicin. | ||
<ref name="TRPV1 dans les neuropathies douloureuses"> A. Danigo, L. Magy et C. Demiot , Med Sci (Paris) Volume 29, Number 6-7, Juin–Juillet 2013, p. 597-606. TRPV1 dans les neuropathies douloureuses, https://www.medecinesciences.org/en/articles/medsci/full_html/2013/08/medsci2013296-7p597/medsci2013296-7p597.html, (Consulted the : dec. 23, 2021). [Online].</ref> | |||
====Resiniferatoxin (RTX)==== | ====Resiniferatoxin (RTX)==== | ||
