2hne: Difference between revisions

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==Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. campestris str. ATCC 33913==
==Crystal structure of l-fuconate dehydratase from xanthomonas campestris pv. campestris str. ATCC 33913==
<StructureSection load='2hne' size='340' side='right'caption='[[2hne]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2hne' size='340' side='right'caption='[[2hne]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hne]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HNE FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HNE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hne OCA], [https://pdbe.org/2hne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hne RCSB], [https://www.ebi.ac.uk/pdbsum/2hne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hne ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2hne TOPSAN]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yey|1yey]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-fuconate_dehydratase L-fuconate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.68 4.2.1.68] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hne OCA], [http://pdbe.org/2hne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hne RCSB], [http://www.ebi.ac.uk/pdbsum/2hne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hne ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2hne TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FUCD_XANCP FUCD_XANCP]] Plays a role in the catabolism of L-fucose. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. L-fuconate is the preferred substrate with 15-fold lower activity observed for L-galactonate and 8-fold lower activity with D-arabinonate. No activity detected with D-fuconate. Can also catalyze the epimerization of L-talonate and D-ribonate, but at slow rates.<ref>PMID:17144652</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hne ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hne ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: L-fuconate dehydratase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Xance]]
[[Category: Almo SC]]
[[Category: Almo, S C]]
[[Category: Burley SK]]
[[Category: Burley, S K]]
[[Category: Fedorov AA]]
[[Category: Fedorov, A A]]
[[Category: Fedorov EV]]
[[Category: Fedorov, E V]]
[[Category: Gerlt JA]]
[[Category: Gerlt, J A]]
[[Category: Yew WS]]
[[Category: Structural genomic]]
[[Category: Yew, W S]]
[[Category: Enolase superfamily]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/2hne"