Sandbox Reserved 1091: Difference between revisions
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The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. For example, the prothrombin system activation promotes plasma coagulation. | The ASP induced '''proteolysis digestion of proteins''' like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. For example, the prothrombin system activation promotes plasma coagulation. | ||
In the [http://en.wikipedia.org/wiki/Kinin–kallikrein_system '''kallikrein/kinin system'''], the ASP | In the [http://en.wikipedia.org/wiki/Kinin–kallikrein_system '''kallikrein/kinin system'''], the ASP induces the production of kinin from kininogen (low MW or high MW). The kinin also released caused edema at the infection site and shock in the circulation. <ref>Mechanisms of Inflammation and Tissue Repair. Gary S. Firestein, Goldman’s Cecil Medicine (Twenty Fourth Edition) (2012)</ref> | ||
Experiments have been done to try to reduce the virulence activity of ASP. It has been demonstrated that the [http://fr.wikipedia.org/wiki/Alpha-2_macroglobuline α2-macroglobulin], a plasma protein, can limit ASP activity. This protein can bind to ASP which is thus inactivated. <ref>Inhibition of Aeromonas sobria serine protease (ASP) by α2-macroglobulin. Murakami Y et al. Biol Chem. 393(10):1193-200 (2012)</ref> | Experiments have been done to try to reduce the virulence activity of ASP. It has been demonstrated that the [http://fr.wikipedia.org/wiki/Alpha-2_macroglobuline α2-macroglobulin], a plasma protein, can limit ASP activity. This protein can bind to ASP which is thus inactivated. <ref>Inhibition of Aeromonas sobria serine protease (ASP) by α2-macroglobulin. Murakami Y et al. Biol Chem. 393(10):1193-200 (2012)</ref> | ||
