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== Composition and 3D structure <ref>DOI 32025030</ref> ==
== Composition and 3D structure <ref>DOI 32025030</ref> ==
=== Global structure ===  
=== Global structure ===  
Human thyroglobulin is a dimeric glycoprotein consisting of 2749 amino acid residues with a molecular weight of 660 kDa. The average size of the dimer is 120x235 Å.  
'''Human thyroglobulin''' is a dimeric glycoprotein (see a <scene name='86/868183/Monomer_tg/1'>monomer</scene> and its stacking with the other)consisting of 2749 amino acid residues with a molecular weight of 660 kDa. The average size of the dimer is 120x235 Å.  
   
   
Each of its monomers comprises 5 distinct regions on which approximately 66 <scene name='86/868183/Tyr/2'>tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions :  
Each of its monomers comprises 5 distinct regions on which approximately 66 <scene name='86/868183/Tyr/2'>tyrosines</scene> (chain A in blue, chain B in green, chain C in dark red, chain D in light red) are distributed. These are the regions :