Sandbox Reserved 1098: Difference between revisions
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==6HMM== | ==6HMM== | ||
<StructureSection load='6hmm' size='340' side='right' caption='[[6hmm]]' scene=''> | <StructureSection load='6hmm' size='340' side='right' caption='[[6hmm]]' scene=''> | ||
The <scene name='82/829351/6hmm/2'>6HMM protein</scene> is a human[[ poly (ADP-ribose) glycohydrolase]]. | The <scene name='82/829351/6hmm/2'>6HMM protein</scene> is a human[[ poly (ADP-ribose) glycohydrolase]]. | ||
is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. | |||
This protein is only present when the DNA is damaged. It influences the damaged chromatin through a derepression of a gene promoter. Consequently this protein is quite interesting for biotechnological applications. Indeed, knowing the different pathways and protein interactions leading to DNA damage repair is a meaningful goal in research especially in new cancer therapies. | |||