Sandbox Reserved 1647: Difference between revisions

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==Introduction==

<scene name='86/868180/Tbx21/3'>TBX21</scene> (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. These transcription factors are known to be specialised in the regulation of developmental processes, especially with immune cells. The DNA binding domain of T-bet has a dimer structure composed of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Tbx21_on_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop. The main function of this transcription factor is to direct [https://en.wikipedia.org/wiki/T_helper_cell TH1 cells differentiation] from naive CD4+ cells. T-bet is cooperating with <scene name='86/868180/Stat4/1'>the N-~~ter~~ domain of Stat4</scene> (signal transducer and activator of transcription 4) for Th1 gene expression <ref name="">TBX21/T-Bet polyclonal antibody : https://www.thermofisher.com/antibody/product/TBX21-T-bet-Antibody-Polyclonal/13700-1-AP</ref>. Nevertheless, the action field of T-bet is larger than classical T-box protein.

<scene name='86/868180/Tbx21/3'>TBX21</scene> (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. These transcription factors are known to be specialised in the regulation of developmental processes, especially with immune cells. The DNA binding domain of T-bet has a dimer structure composed of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Tbx21_on_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop. The main function of this transcription factor is to direct [https://en.wikipedia.org/wiki/T_helper_cell TH1 cells differentiation] from naive CD4+ cells. T-bet is cooperating with <scene name='86/868180/Stat4/1'>the amino-terminal domain of Stat4</scene> (signal transducer and activator of transcription 4) for Th1 gene expression <ref name="">TBX21/T-Bet polyclonal antibody : https://www.thermofisher.com/antibody/product/TBX21-T-bet-Antibody-Polyclonal/13700-1-AP</ref>. Nevertheless, the action field of T-bet is larger than classical T-box protein.

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 ==Introduction==
-<scene name='86/868180/Tbx21/3'>TBX21</scene> (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. These transcription factors are known to be specialised in the regulation of developmental processes, especially with immune cells. The DNA binding domain of T-bet has a dimer structure composed of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Tbx21_on_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop. The main function of this transcription factor is to direct [https://en.wikipedia.org/wiki/T_helper_cell TH1 cells differentiation] from naive CD4+ cells. T-bet is cooperating with <scene name='86/868180/Stat4/1'>the N-ter domain of Stat4</scene> (signal transducer and activator of transcription 4) for Th1 gene expression <ref name="">TBX21/T-Bet polyclonal antibody : https://www.thermofisher.com/antibody/product/TBX21-T-bet-Antibody-Polyclonal/13700-1-AP</ref>. Nevertheless, the action field of T-bet is larger than classical T-box protein.
+<scene name='86/868180/Tbx21/3'>TBX21</scene> (for t-box transcription factor 21) or T-bet is a [https://en.wikipedia.org/wiki/Transcription_factor transcription factor], more precisely a [[T-box proteins]]. These transcription factors are known to be specialised in the regulation of developmental processes, especially with immune cells. The DNA binding domain of T-bet has a dimer structure composed of two identical chains (<scene name='86/868180/Chain_a/2'>A</scene> / <scene name='86/868180/Chain_b/2'>B</scene> ) with a total molecular weight of 76,37 kDA. This binding domain allows the protein to bind itself on the DNA promotor or regulator area. T-box protein is able to <scene name='86/868180/Tbx21_on_dna/1'>link two DNA molecules with only one dimer</scene>. Moreover, it is able to link two areas of the same DNA molecules which are far from each other and thus create a chromatin loop. The main function of this transcription factor is to direct [https://en.wikipedia.org/wiki/T_helper_cell TH1 cells differentiation] from naive CD4+ cells. T-bet is cooperating with <scene name='86/868180/Stat4/1'>the amino-terminal domain of Stat4</scene> (signal transducer and activator of transcription 4) for Th1 gene expression <ref name="">TBX21/T-Bet polyclonal antibody : https://www.thermofisher.com/antibody/product/TBX21-T-bet-Antibody-Polyclonal/13700-1-AP</ref>. Nevertheless, the action field of T-bet is larger than classical T-box protein.
 ==Location==