6pl0: Difference between revisions
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==Crystal structure of the dark-adapted full-length bacteriophytochrome XccBphP from Xanthomonas campestris in the Pr state bound to BV chromophore== | ==Crystal structure of the dark-adapted full-length bacteriophytochrome XccBphP from Xanthomonas campestris in the Pr state bound to BV chromophore== | ||
<StructureSection load='6pl0' size='340' side='right'caption='[[6pl0]]' scene=''> | <StructureSection load='6pl0' size='340' side='right'caption='[[6pl0]], [[Resolution|resolution]] 2.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PL0 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6pl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanc8 Xanc8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PL0 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLA:BILIVERDINE+IX+ALPHA'>BLA</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5akp|5akp]]</div></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bphP, XC_4241 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=314565 XANC8])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pl0 OCA], [https://pdbe.org/6pl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pl0 RCSB], [https://www.ebi.ac.uk/pdbsum/6pl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pl0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/BPHY_XANC8 BPHY_XANC8]] Photoreceptor which exists in two forms that are reversibly interconvertible by light: far-red light (733 nm) converts protein to the red-absorbing (Pr) form, while red light (630 nm) partly converts the protein to the far-red-absorbing (Pfr) form (PubMed:27107635). Regulates virulence of X.campestris pv. campestris on its host plants, perhaps by fine-tuning expression to ambient light levels and/or spatial cues (PubMed:27621284). The Pr form may sense light and partially inhibit virulence; in the dark (Pfr form) biofilm and xanathan production rise and bacteria are more virulent (PubMed:27621284). Strains overexpressing this protein have significantly decreased amounts of extracellular beta-1,4-endoglucanase, produce less xanthin and have decreased transcription of genes involved in virulence such as endoglucanases, type 2 secretion systems, xanthan production and flagellar-dependent motility (PubMed:27621284).<ref>PMID:27107635</ref> <ref>PMID:27621284</ref> <ref>PMID:27621284</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
[Figure: see text]. | |||
Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level.,Otero LH, Foscaldi S, Antelo GT, Rosano GL, Sirigu S, Klinke S, Defelipe LA, Sanchez-Lamas M, Battocchio G, Conforte V, Vojnov AA, Chavas LMG, Goldbaum FA, Mroginski MA, Rinaldi J, Bonomi HR Sci Adv. 2021 Nov 26;7(48):eabh1097. doi: 10.1126/sciadv.abh1097. Epub 2021 Nov, 24. PMID:34818032<ref>PMID:34818032</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6pl0" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bonomi | [[Category: Xanc8]] | ||
[[Category: Chavas L]] | [[Category: Bonomi, H R]] | ||
[[Category: Goldbaum F]] | [[Category: Chavas, L]] | ||
[[Category: Klinke S]] | [[Category: Goldbaum, F]] | ||
[[Category: Otero | [[Category: Klinke, S]] | ||
[[Category: Rinaldi J]] | [[Category: Otero, L H]] | ||
[[Category: Sirigu S]] | [[Category: Rinaldi, J]] | ||
[[Category: Sirigu, S]] | |||
[[Category: Bacterial protein]] | |||
[[Category: Photoreceptor]] | |||
[[Category: Photosensor]] | |||
[[Category: Phytochrome]] | |||
[[Category: Phytopathogen]] | |||
[[Category: Red/far-red light]] | |||
[[Category: Signal transduction]] | |||
[[Category: Signaling protein]] | |||
Revision as of 10:01, 12 January 2022
Crystal structure of the dark-adapted full-length bacteriophytochrome XccBphP from Xanthomonas campestris in the Pr state bound to BV chromophore
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