7n13: Difference between revisions
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==Crystal structure of MTH1 in complex with compound 32== | ==Crystal structure of MTH1 in complex with compound 32== | ||
<StructureSection load='7n13' size='340' side='right'caption='[[7n13]]' scene=''> | <StructureSection load='7n13' size='340' side='right'caption='[[7n13]], [[Resolution|resolution]] 1.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N13 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7n13]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N13 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n13 OCA], [https://pdbe.org/7n13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n13 RCSB], [https://www.ebi.ac.uk/pdbsum/7n13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n13 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZRV:4-anilino-6-[4-(butylcarbamoyl)-3-fluorophenyl]-N-cyclopropyl-7-fluoroquinoline-3-carboxamide'>ZRV</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7n03|7n03]]</div></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n13 OCA], [https://pdbe.org/7n13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n13 RCSB], [https://www.ebi.ac.uk/pdbsum/7n13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n13 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Eron | [[Category: Eron, S J]] | ||
[[Category: Hydrolase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Inhibitor]] | |||
Revision as of 10:04, 12 January 2022
Crystal structure of MTH1 in complex with compound 32
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